职称：副教授          职务：教研室主任

教学经历：

2017年-至今 金沙威尼斯欢乐娱人城医学院 副教授

2017年-至今 锦州医科大学 硕士研究生导师

本人从事医学教育8年，讲授课程有：《医学细胞生物学》、《医学分子生物学》、《医学文献检索与论文写作》等。

教科研项目及代表性成果：

一、主持或参加教学科研项目

（1）国家自然科学基金项目，82060118，ABHD10受EGR1直接调控诱导肝细胞EMT促肝纤维化的机制研究，2021.01-2024.12，在研，主持。

（2）内蒙古自治区高等学校科学研究项目，NJZY20203，索拉菲尼（sorafenib) 通过下调ELK-3抑制上皮-间质转化及改善肝纤维化的机制研究，2020.01- 2022.12，在研，主持。

（3）内蒙古自然科学基金项目，2015MS0801，ELK3在上皮细胞-间充质转化及肝癌细胞侵袭和转移中的作用机制，2015.01-2017.12，已结题，主持。

（4）国家自然科学基金项目，81860496，5-脂氧合酶基因变异促进食管癌发生发展的遗传分子机制研究，2019.01-2022.12，在研，参加（第二）。

（5）国家自然科学基金项目，81760200，Toll样受体在IgG4相关性唾液腺炎发病中的作用及其机制研究，2018.01-2021.12，在研，参加（第一）。

（6）内蒙古自然科学基金项目，2019BS08006，肿瘤双重靶向性线性五肽-透明质酸-阿霉素纳米粒子的研究，2019.01-2021.12，在研，参加（第一）。

二、代表性论文

1. Tian Zhu Li, Sung Min Kim, Wonhee Hur, et al. Elk-3 contributes to the progression of liver fibrosis through regulating epithelial-mesenchymal transition. Gut Liver, 15;11(1):102-111, 2017

2. Tian Zhu Li, Cheng Zhe Jin, Byung Hyune Choi, et al. Using cartilage extracellular matrix (CECM) membrane to enhance the reparability of the bone marrow stimulation technique for articular cartilage defect in canine model. Adv Funct Mater, 22:4292-300, 2012

3. Tian Zhu Li, Jae Hyung Kim, Hyun Hee Cho, et al. Therapeutic potential of bone marrow-derived mesenchymal stem cells differentiated with growth factor-free co-culture method in liver-injured rats. Tissue Eng Part A, 16(8):2649-59, 2010

4. Tian Zhu Li, Sang-Hyun Shin, Hyun Hee Cho, et al. Growth factor-free cultured rat bone marrow derived mesenchymal stem cells towards hepatic progenitor cell differentiation. Biotechnol Bioprocess Eng, 13:659-65, 2008

5. Xu WT, Li TZ, Li SM, et al. Cytisine exerts anti-tumour effects on lung cancer cells by modulating reactive oxygen species-mediated signalling pathways. Artif Cells Nanomed Biotechnol, 48(1):84-95, 2020

6. Wang JR, Li TZ, Wang C, et al. Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway. Naunyn Schmiedebergs Arch Pharmacol, 393(10):1987-1999. 2020

7. Xu WT, Shen GN, Li TZ, et al. Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS regulated MAPK, STAT3 and NF κB signaling pathways. Int J Oncol, 57(2):550-561. 2020

8. Sung Min Kim, Jung Eun Choi, Wonhee Hur, Jung Hee Kim, Sung Woo Hong, Eun Byul Lee, Joon Ho Lee, Tian Zhu Li, et al. RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis. J Cell Biochem，118(8):2026-2036, 2017

9. Jae Hyung Kim, Sang-Hyun Shin, Tian Zhu Li, et al. Influence of in vitro bio-mimicked stem cell “Niche” for regulation on proliferation and differentiation of human bone-marrow derived mesenchymal stem cells into myocardial phenotypes: serum starvation without aid of chemical agent and prevention of spontaneous stem cell transformation enhanced by matrix environment. J Tissue Eng Regen Med, 10(1):E1-13, 2016

10. Jung Eun Choi, Wonhee Hur, Jung-Hee Kim, Tian Zhu Li, et al. MicroRNA-27a Modulates HCV Infection in Differentiated Hepatocyte-like Cells from Adipose Tissue-derived Mesenchymal Stem Cells. Plos One, 13:9(5):e91958, 2014

11. Sung Woo Kim, Wonhee Hur, Tian Zhu Li, et al. Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. Experimental & Molecular Medicine, 46:e92, 2014

12. Jae Won Choi, Byung Hyune Choi, Sang-Hyug Park, Ki Soo Pai, Tian Zhu Li, et al. Mechanical stimulation by ultrasound enhances BM-MSC chondrogenic differentiation in a fibrin-HA hydrogel. Artif Organs, 37(7):648-55, 2013

13. Jae Hyung Kim, Kyoo-Ho Shin, Tian Zhu Li, Hwal Suh. Potential of nucleofected human MSCs for insulin secretion. J Tissue Eng Regen Med, 5(10):761-9, 2011

14. Jung Mi Han, Byung Joon Chang, Tian Zhu Li, et al. Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo. Brain Res, 1185:68-74 , 2007

15. 李天柱，史铁伟，周静，等. 干扰ELK-3抑制肝癌细胞的上皮-间质转换. 基础医学与临床，37(2):211-216. (北大中文核心), 2017

16. 李天柱，王加茹，张俊毅，等. ELK-3蛋白在肝癌组织中的表达及其对肝癌HepG2细胞迁移和侵袭能力的影响. 吉林大学学报（医学版）, 2018;44(4):736-740.（北大中文核心），2018

三、论文之外的代表性成果（专利、专著、教材、获奖等）